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In mammalian species these cells migrate into the thyroid gland during development and occupy a characteristic central location at the junction of the upper one-third and lower two-thirds of each thyroid lobe
This not only fixes the deficiency but also makes life better for those affected
Structurally, it contains an extracellular N-terminal domain (NTD) and a transmembrane domain (TMD) with -helix bundles (Wu et al., 2020)
For instance, sometimes patients with Parkinsons disease, whose brains struggle to produce dopamine, will often go on dopamine replacement therapy
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