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Furthermore, the risks of myocardial infarction (HR 0.91, 95% CI 0.840.98 with GLP-1RAs and HR 0.89, 95% CI 0.800.98 with SGLT2is) and cardiovascular death (HR 0.88, 95% CI 0.800.96 with GLP-1RAs and HR 0.84, 95% CI 0.750.94 with SGLT2is) were similarly reduced in both GLP-1RA and SGLT2i groups, while the risk of stroke was reduced only with GLP-1RAs (HR 0.86, 95% CI 0.770.97 with GLP-1RAs and HR 0.97, 95% CI 0.861.10 with SGLT2is)

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Randomized, double-blind clinical trial, controlled with placebo, of the toxicology of chronic melatonin treatment