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In animal and cell studies it is associated with upregulation of repair-related growth-factor and angiogenic signalling (for example VEGF-linked pathways), collagen and extracellular-matrix (ECM) remodelling, and modulation of inflammation, which underlies research interest in connective-tissue and gut-lining recovery
It was found that transgenic mice developed HCC, which subsided when the transgene was inhibited, which showed that Met over-expression induced tumorigenesis without HGF
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