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10.1056/NEJMsr1606602 32 LeeH.LeeY.KimJ.AnJ.LeeS.KongH.et al (2018)
Conclusion TZP appears a potent tool to improve glucose control without increasing hypoglycemic risk in poorly controlled T2D treated with basal insulin with or without other antihyperglycemic oral agents
Weight loss, AHI reduction, and metabolic outcomes from clinical trials reflect average effects in study populations
Above that threshold, additional methionine or choline doesn't compound the effect because the liver's methylation enzyme capacity is saturated
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