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Retatrutide is an investigational triple agonist targeting GLP-1, GIP, and glucagon receptors simultaneously, but it remains unlicensed in the UK and is only available within regulated clinical trials
Like exenatide, lixisenatide demonstrates reliable control of blood glucose and provides modest weight loss, typically less than 3 kg depending on the duration of treatment (Sheng et al., 2024)
Overdosage of up to 4mg per week has been reported in clinical trials, with patients experiencing nausea
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