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The metabolic pathway of BPC-157 involves rapid breakdown into various small peptide fragments in vivo, ultimately forming single amino acids that enter normal amino acid metabolism and excretion pathways
The result is a spectrum from relatively permissive to highly restrictive
For example, cotargeting IL-6/JAK/STAT3 signaling and the PD-1/PD-L1 axis may overcome immune resistance in PD-L1 high tumors with elevated IL-6
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