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MNs/GLP-1RAs@NPs-WYRGRL suppressed the progression of RA through promoting the polarization of synovial macrophages to the M2 type To clarify whether MNs/GLP-1RAs@NPs-WYRGRL could alleviate the inflammatory response of RA by regulating the polarization state of synovial macrophages, this study detected the types of synovial macrophages and the cytokines they secrete in each group

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In cases where significant main effects or interactions were observed, single degree of free contrasts were performed to determine specific effects without adjustment of the acceptable level of significance