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This rapid degradation is the primary reason that GLP-1 receptor agonist drugs require structural modifications such as DPP-4 resistance mutations, albumin binding, or Fc fusion to achieve a pharmacologically useful duration of action
Some people experience mild nausea, a slight headache, or fatigue
This molecule, termed exendin-4, was found in the saliva of a lizard species known as the Heloderma suspectum
Neuropsychobiology, 9 (4), 197-206
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