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When intake is insufficient affecting an estimated one billion people worldwide [6] the selenide pool is depleted, Sec-tRNA [Ser]Sec charging falls, and the hierarchy described in Section 6 is engaged: nonessential selenoproteins are downregulated first, compromising antioxidant defense and selenium redistribution, followed by essential ones as deficiency deepens
Over time (usually weeks to months), your skin tone gradually returns to its natural shade
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