In healthy individuals, the kidneys filter 2,0002,400 mg of magnesium daily, 120 and there is little risk associated with the use of magnesium at doses commonly used for laxative purposes
However, a growing body of evidence reveals a pronounced immunoinflammatory phenotype in OA, wherein macrophages, T/B lymphocytes, and inflammatory factors such as IL-1, TNF-, and IL-6 play a critical role in the local microenvironment (105)
Potential side-effects, interactions (especially in vulnerable populations)
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