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The historical registration of some extract preparations (such as thymalin, epithalamin, and cortexin) within Russia does not constitute approval in Western regulatory systems, which apply far more stringent efficacy, manufacturing, and pharmacovigilance requirements before a product may be marketed for human use
However, exclusive use of folic acid in treating vitamin B12 deficient megaloblastic anemia could result in progressive and irreversible neurologic damage
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PMID: 29422987
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