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A full-thickness skin wound with a diameter of 6 mm was created on the dorsal region of each mouse
Further studies found that overexpression of GLP-1R enhanced the anti-diabetic effect of daphnetin and significantly reduced inflammation and oxidative stress, while silencing GLP-1R weakened the health benefits of daphnetin
Yet products commonly contain 1% or higher, delivering concentrations millions of times greater than the minimum effective dose
For example, women in their 40s notice a declining appearance of their facial areas with drier skin and more pronounced wrinkles [2, 10, 14]
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