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Nature Rev Genet
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The BBB employs various transport systems, such as carrier-mediated transport (CMT), receptor-mediated transport (RMT), active efflux transport, vesicular trafficking by transcytosis, and ion transport, to facilitate the entry of essential substances into the brain parenchyma and the efflux of metabolic waste and endogenous neurotoxins [19, 23]
Medications like semaglutide (Wegovy) and tirzepatide (Zepbound) are powerful tools, and like any powerful tool, they work best when used with knowledge and preparation
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