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Funding This work was supported by the Hubei Provincial Natural Science Foundation of China (2024AFB494 to Mi Chen), Hubei Provincial Natural Science Foundation and Xianning of China(2025AFD391 to Youzhi Zhang)and the Foundation of Hubei University of Science & Technology Science (No
However, there is currently a lack of comprehensive longitudinal in vivo studies assessing NP biodistribution, clearance kinetics, and immune responses in AD-relevant models
For example, studies have shown that certain components of Chinese medicine can improve depressive symptoms by modulating the metabolites of gut microbiota, such as the hydrolysis of fatty acid amides, which in turn influences host neurotransmitter levels [601]
When pain is detected, serotonergic neurons in the brainstem (in a region called the rostral ventromedial medulla) are activated and release serotonin
