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In ovarian cancer cell lines SKOV-3 and OVCAR-3, Ex-4 induces apoptosis by modulating NF-B downstream targets, including matrix metalloproteinase-9 (MMP-9), intercellular adhesion molecule-1(ICAM-1), BAX, Bcl-2, and cyclin D [68]

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Reduced glutathione (GSH) can react with dinitrobenzoic acid (DNTB) to form a yellow complex which can be detected by colorimetric assay at 405 nm and calculate the reduced GSH content indirectly

However, current fluorescent imaging techniques may underestimate brain penetrance, and better techniques will be needed to get a fuller picture of which GLP-1 receptors are reached by systemically administered GLP-1R agonists