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It competitively binds p53, displacing endogenous FOXO4 in senescent cells (Baar et al., 2017) 24-72 hours: Freed p53 translocates to mitochondria in senescent cells, triggering the intrinsic apoptotic cascade

Additionally, the generation of hydrogen peroxide by the FLCs further intensifies the renal injury, stimulating the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B) and apoptosis signal-regulating kinase 1 (ASK1), as well as the Janus kinases(JAK) and signal transducer and activator of transcription proteins (STATs) pathway [78]

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