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This approach, which often involves applying a fraction of the standard dose, is designed to investigate the cellular or physiological responses without provoking the full-blown effects of the drug

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showed that NOX2 oxidase, the primary enzymatic source of ROS, is activated by single-stranded RNA and DNA viruses in endocytic compartments, inducing endosomal H 2 O 2 generation, thereby suppressing the antiviral and humoral signaling networks by modifying the unique highly conserved cysteine residue on Toll-like receptor (TLR)-7 42