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In order to overcome the short half-life of GLP-1 and improve stability, researchers at Novo Nordisk used genetic engineering techniques to modify the amino acid sequence of GLP-1 to produce a more stable and long-lasting analogue, insulin-like Peptide-1 receptor agonist (GLP-1 RA)
[3] Jastreboff AM, Kaplan LM, Fras JP, Wu Q, Du Y, Gurbuz S, Coskun T, Haupt A, Milicevic Z, Hartman ML
These complexes activate toll-like receptors 7 and 9 on dendritic cells, essentially tricking the immune system into treating the body own genetic material as a foreign invader
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