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Long-term safety and efficacy data are also essential

Apart from nuclear localization, the hinge region, and in particular its 629-RKLKKL-634 motif, was also found to play a complex role in DNA binding, coactivator recruitment, and N/C interaction 55,56 and is a target site for acetylation, ubiquitylation and methylation 56

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As summarized previously, a number of studies have revealed the impact of the gut microbiota on bone health and highlighted, for example, the role of bone metabolism by modulating the immune system, metabolic pathways, and hormonal dynamics