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A recent letter in Annals of Internal Medicine led by my colleagues Tim Kambi and Jan Karregat highlights this issue clearly: Similarly, work by my colleague Carla Prado, PhD, RD, FCAHS underscores that reductions in lean mass during GLP-1induced weight loss are common
In the context of tirzepatide versus glutathione selection, these genetic markers can highlight whether your biology favors direct hormone-receptor targeting or if metabolic inflammation and oxidative stress are primary drivers of weight gain
Of 41,792 patients who discontinued and had post-discontinuation weight data, 1-year reinitiation was lower in patients without T2D (36.3% restarted within a year) compared to those with T2D (47.3% restarted within a year)
Data availability The data underlying the results presented in this study are available from the corresponding author upon submission of a legitimate request
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