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Although current evidence supports broad applicability across BMI, diabetes status, and fibrosis stages F2-F3, subgroup analyses suggest attenuated responses in non-obese patients and in certain ethnic groups (Hispanic patients in ESSENCE), emphasizing the need for precision medicine approaches incorporating anthropometric, genetic (e.g., PNPLA3, HSD17B13), and metabolic profiling

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Studies that were analyzed evaluated the effects of these agents on anxiety, depression, psychosocial functioning in schizophrenia, dementia, cognitive functioning, substance use disorders such as cocaine and alcohol, and behavioral problems in autism