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Accumulation of ethanol-associated reactive molecules, e.g., reactive oxygen (ROS) and nitrogen species (RNS), and electrophilic products, e.g., acetaldehyde and lipid peroxidation-derived products, can be harmful to biological systems due to their propensity to inactivate enzymes, leading to loss of protein function, DNA damage and cell death 4

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A retrospective case series reported that, although the frequency of paracetamol poisoning is lower in older subjects, when paracetamol intoxication does occur, it is more frequently associated with fulminant hepatic failure and death and age is considered an independent risk factor of morbidity and mortality in these cases [61]