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The initial inflammatory modulation begins within the first one to two weeks, but the functional changes, including improved flexibility, reduced global stiffness, and better circulation, accumulate over four to eight weeks as the compounds systemic effects build through repeated dosing
No direct stack RCT has evaluated the combination in humans
But including foods high in these vitamins (like whole grains, meats, eggs, dairy, leafy greens, nuts) as tolerated can help maintain levels once the course of injections is over
Some people also give themselves injections under the skin
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