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Nonclinical Toxicology 13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility Rats and mice treated with amlodipine maleate in the diet for up to two years, at concentrations calculated to provide daily dosage levels of 0.5, 1.25, and 2.5 amlodipine mg/kg/day, showed no evidence of a carcinogenic effect of the drug
Hyperactivation of Nrf2 Increases Stress Tolerance at the Cost of Aging Acceleration Due to Metabolic Deregulation
May not be enough: They may not be sufficient for significant injury, severe metabolic dysfunction, or advanced disease states
Brain Res 660(1):154
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