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Non-selective c-Met inhibitors include crizotinib (PF-02341066), foretinib (XL-880), cabozantinib (XL-184), glesatinib (MGCD265), BMS-777607, and MK2461, which in addition to c-Met, can inhibit other tyrosine kinases, such as ALK, RON, VEGFR2, KIT, TIE2, PDGFR, VEGFR1, VEGFR3, RET, and FLT-3 [163,164,165], through binding to the ATP binding site on tyrosine kinases
These menstrual changes result from fluctuations in estrogen and progesterone, which directly affect the ovaries and the uterine lining
Shared decision-making should therefore integrate patient priorities regarding weight reduction, treatment tolerability, cost, timing of conception, and readiness for OI or ART, rather than relying on body weight alone as the sole marker of success
But the official regulatory framework covers only the diabetes indication at this time
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