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Semaglutide is safe for diverse patient populations and treatment durations, but it still has some side effects to be aware of: Anxiety Blurred vision Constipation Diarrhea Faster heartbeat Fatigue Fever Headaches Lightheadedness Nausea Shakiness or weakness Stomach pain Sweating Vomiting Yellow skin or eyes In one study, about one third of patients reported some side effects, though many were manageable