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Potential harms of frequent venesection therapy for a person without true iron overload include development of iron deficiency anaemia, reinforcement of a suboptimal management strategy for a biochemical abnormality, perpetuation of the myth that a genetic condition affecting family members exists, and the general venesection risks of venous scarring, phlebitis and vasovagal episodes

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For longitudinal measures approach (baseline, middle of treatment, end of treatment, and follow-up period), a mixed linear regression with a random effect on the individual to estimate the mean change score in each category of patients were used