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These drugs work by mimicking the action of naturally occurring GLP-1, an incretin hormone that stimulates insulin secretion in response to food intake, suppresses glucagon release, and slows gastric emptying

Side effects are the number one reason people discontinue semaglutide prematurely, and most of those side effects are manageable with the right strategies

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Gradual cold exposure may help the body adapt, but sudden exposure to very cold environments can be uncomfortable