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The assumption of proportional hazards was evaluated with the generalized Schoenfeld approach on the TriNetX platform, with aHRs recalculated for specific time frames if initial assumptions were not met

Model 4 was adjusted for variables in model 3, as well as for the average daily dosage of metformin and sulfonylureas after the cohort entry, and other retinal disorders

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Safety & Tolerability Preclinical Findings : IGF-1 LR3 demonstrates potent biological activity but requires strict dosing in experimental settings