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The resulting systemic cytokine storm coincides with ROS attacking tight junction proteins in capillary endothelial cells, inducing microcirculatory leakage [412]
As mentioned previously, NRF2 regulates the expression of ATF4, which controls the expression of the glutamine transporter SLC1A5 [73], and asparagine synthetase (ASNS), which generates both asparagine and glutamate from aspartate and glutamine
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The relationship between Candida and hormonal imbalance is bidirectional: oestrogen promotes Candida adherence and proliferation, while Candida produces oestrogen-mimicking compounds (mycoestrogens) and impairs hepatic oestrogen metabolism, worsening oestrogen dominance
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