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Findings from research models should not be interpreted as evidence of safety or effectiveness in humans or animals
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MLN3897 Plus Methotrexate in Patients With Rheumatoid Arthritis: Safety, Efficacy, Pharmacokinetics, and Pharmacodynamics of an Oral CCR1 Antagonist in a Phase IIa, Double-Blind, Placebo-Controlled, Randomized, Proof-of-Concept Study
A 2017 RCT confirmed that even a double-conjugated retinoid formulation caused significantly more erythema than vehicle, though it was more tolerable than standard tretinoin
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