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APT Enzyme Modulators: The activity of depalmitoylases is equally critical in shaping cell fate, as demonstrated by emerging chemical tools

Although additional studies are required to clarify the molecular mechanisms responsible for hyperhomocysteinemia-induced vascular disorders, there is evidence that the direct cytotoxicity of markedly elevated homocysteine and/or of its oxidized by-products (homocysteine thiolactone, homocysteine sulfinic acid, and homocysteic acid) damages endothelial cells (Dudman et al, 1991

Barth E, Stammler G, Speiser B, Schaper J