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The body-weight difference was -1.92 kg (95% CI -2.91 to -0.93), again favouring semaglutide

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Discussion In the present study, we found that GLP-1R protein levels decreased significantly in a knee OA rat model induced by monoiodoacetate, which was accompanied by the downregulation of the PKA/CREB pathway and upregulation of the inflammation-related proteins TNF-, IL-6 and IL-1

For a software-as-a-medical-device (SaMD) product with annual software updates, determining what constitutes a significant change requiring new PMCF evaluation adds regulatory complexity to the product development cycle