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The combination arm was terminated early due to severe adverse events and deaths, while NAC alone showed no significant effect on lung function, though secondary endpoints (6MWD, QoL) improved modestly (139)

The American College of Cardiology recommends continuing baseline statin therapy, as GLP-1 receptor agonists provide complementary cardiovascular benefits rather than serving as statin substitutes

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Global, regional, and national burden of neck pain, 19902020, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021