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doi:10.1016/j.jaad.2011.04.031

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Because glutathione is vital for nearly all cells, the symptoms of glutathione deficiency are widespread, including: Chronic fatigue or brain fog Recurrent illnesses or slow illness recovery Poor detoxification (signs include intolerance to smells, jewelry, or personal care products

The rate of weight loss may also influence the degree of cold intolerance, though this observation is primarily based on clinical experience rather than controlled studies