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Inflammatory markers like C-reactive protein and TNF-alpha are often elevated in people with both obesity and arthritis, suggesting that fat tissue actively contributes to joint inflammation
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[7] [19] Proposed mechanisms include affecting GABA levels, blocking voltage-gated sodium channels, inhibiting histone deacetylases, and increasing LEF1
Individual experiences can vary, and some may find the fatigue persists for longer or resolves more quickly
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