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What the Research Says In a 2020 double-blind clinical study, participants who supplemented with MSM for 16 weeks experienced improvements in skin firmness, elasticity, hydration, and a significant reduction in the appearance of fine lines and wrinkles (Muizzuddin et al., 2020)

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In this regard, when used in combination, these pharmacological agents complement each other to correct several components of the Ominous Octet described by DeFronzo (11)