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Taking a separate sublingual methylcobalamin supplement of 1000 mcg or more daily will provide significantly more B12 than the 100 mcg in the compounded ODT

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10-14 The Diabetes Control and Complications Trial demonstrated a relationship between improved blood glucose control and increased risk of early worsening of DR, as well as between long-term risk reduction of DR with sustained blood glucose improvement

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The semaglutide B12 dosage chart follows the same escalation pattern but includes B12 dosing considerations

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