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While 24-h urine calcium excretion increased on average 50 mgday 1 greater than placebo, there was no greater risk of clinical nephrolithiasis, though pre-existing kidney stones were an exclusionary criteria for trial randomization

Think of it as the difference between trying to redirect a river all at once versus slowly shifting its course over time

Faheem Najeeb Functional & Integrative Medicine Practitioner, Medical Director, Tigris Valley