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Creatine supplementation may help preserve or rebuild muscle when combined with consistent strength training and 1.62.2 g/kg daily protein

Rapid weight loss (which is more characteristic of GLP-1s) can accelerate this process if not properly managed. A systematic review and meta-analysis published in The American Journal of Clinical Nutrition of 41 trials involving 15,135 participants showed that individuals taking GLP-1s showed a significant reduction in metrics, including body weight, body mass index (BMI), and waist circumference

It further notes that if a mother requires tirzepatide, it is not a reason to discontinue breastfeeding