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Some patients prefer morning administration to allow any mild nausea to resolve during the day, while others may prefer evening injection if they experience fatigue or other symptoms following administration

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However, unlike ghrelin itself, Ipamorelin does not significantly affect hunger or gastric motility, which makes it an ideal peptide for studies that require GH release without secondary metabolic effects

Research suggests the peptide may interact with neurotransmitter systems including the dopaminergic, serotonergic, and GABAergic pathways, though these findings remain in the preclinical stage