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The programme spans multiple trials targeting distinct endpoints: On 21 May 2026 Eli Lilly reported topline results from TRIUMPH-1, the pivotal Phase 3 obesity trial and the programme's first Phase 3 efficacy readout: in 2,339 adults, mean weight loss at the 80-week primary endpoint reached 19.0% (4mg), 25.9% (9mg), and 28.3% (12mg) versus 2.2% for placebo (Eli Lilly investor release

Given these complexities, CBO acknowledges a lot of uncertainty involved in these calculations

In this light, the dissection of the complex association between dysmetabolism and PDAC, with a specific focus on stroma, and in particular on P4HA1 role, could help to unveil novel targets for prevention, early diagnosis and intervention aimed at reducing incidence and improving PDAC prognosis

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