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That is why it can be swallowed at all, and why it behaves like a small-molecule drug: real oral absorption, first-pass liver metabolism, a huge volume of distribution (39 L/kg in mice), and off-target enzyme binding
doi: 10.1177/2040622315609312 59 ChristensenMKnopFKHolstJJVilsbollT
Genomic insights on variation underlying capsule expression in meningococcal carriage isolates from university students, United States 20152016
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