During fracture healing, calcium requirements increase to approximately 1200 milligrams per day, and vitamin D levels should be maintained at 30 to 50 nanograms per milliliter (serum 25-hydroxyvitamin D)
Links to ASD-risk genes (TSC1/TSC2, PTEN, FMR1) amplify these effects, producing social deficits, repetitive behaviors, rigidity, and motor incoordination (DeSpenza et al
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Song S, Lee H, Kam T-I, Tai ML, Lee JY, Noh JY, Shim SM, Seo SJ, Kong YY, Nakagawa T, Chung CW, Choi DY, Oubrahim H, Jung YK (2008) E2-25K/Hip-2 regulates caspase-12 in ER stressmediated A neurotoxicity