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GLP1-RAs effects on WL are well-established in the general population and in patients with diabetes [49,50,51,52,53]

Historically, treatment options have been limited to lifestyle modificationspecifically weight loss of 710% of body weight, which can improve hepatic steatosis and inflammation

61 This poly-agonist escalation allows innovators to continually raise the bar for best-in-class therapy, making it harder for first-generation generics to compete on clinical grounds alone