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Experimental studies to elucidate the beneficial effects of GLP-1 RA have mainly implicated the induction of natriuresis and the inhibition of oxidative stress, inflammation, and fibrosis [39,40,41]
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Gastrointestinal symptomsparticularly nausea, vomiting, diarrhoea, and constipationare the most frequently reported adverse effects of GLP-1 receptor agonists, occurring in 2050% of patients depending on the specific agent and dose according to clinical trials and SmPC data
Intriguingly, the LCn treatment significantly ( P 0.05) increased the expression of the StAR gene relative to the control group [Figure 2]
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