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The concern applies to supplemental doses above roughly 3 grams a day, not to dietary arginine
The compound also enhances CD8+ T cell cytotoxicity by upregulating Fas ligand expression and shifting cytokine profiles from Th2-dominant (IL-6, IL-10) to Th1-polarized (IFN-) responses, as demonstrated in renal cell carcinoma models [25]
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Glucose-dependent insulinotropic polypeptide: effects on insulin and glucagon secretion in humans
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