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Patients should also have a clear plan for what happens if the medication is stopped, changed, unavailable, not tolerated, or no longer needed

Some patients find relief by switching from semaglutide injection to oral semaglutide or tirzepatide, as different formulations and compounds engage GLP-1 and GIP receptors slightly differently, potentially producing different side effect profiles

Daily sublingual dosing produces a flatter concentration curve than weekly injection

The most frequent side effects of semaglutide include nausea, vomiting, and diarrhea, which can occur in the first few weeks of treatment but usually improve over time