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Propfe LE et al
Conversely, upregulation of FTL1 and ferritin heavy chain (FTH1), or inhibition of NCOA4, can suppress ferroptosis ( in vitro model of Erastin-induced ferroptosis in PC12 neuronal cells, the iron inhibitor curcuminpolydopamine nanoparticles (Cur-PDA NPs) markedly enhanced the chelation of Fe 3+ and Fe 2+ , upregulated superoxide dismutase (SOD) and GSH expression, reduced Fe 2+ and ROS levels, inhibited lipid peroxidation, restored mitochondrial function, and attenuated neuronal ferroptosis
The therapeutic relevance of brain GLP-1 activity has expanded considerably with the widespread use of GLP-1 receptor agonists such as semaglutide (Ozempic, Wegovy) and liraglutide (Victoza, Saxenda)
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