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Metformin treatment should not be initiated in patients 80 years of age unless measurement of creatinine clearance demonstrates that renal function is not reduced, as these patients are more susceptible to developing lactic acidosis

Because appetite is reduced while taking GLP-1s, every bite needs to count

But along with fewer food cravings, research shows that some people taking these medications may also be at higher risk for dehydration and nutrient shortfalls (3,5)